The Computer Science and Technology discipline at Shenzhen University was founded with support from Tsinghua University in 1983 when the Shenzhen University was just established. College of Computer Science and Software Engineering was formally established in 2008, which was headed by Guoliang Chen, the Academician of the Chinese Academy of Sciences, as its founding Dean. Over the years' development, CSSE has now led by Professor Hui Huang and become a prominent college in education and research nationally and globally.

The platforms include two national-level research platforms (National Engineering Laboratory for the Big Data System Computing Technology, MOE-GD Collaborative Innovation Center for GD-HK Modern Information Service), three national-level teaching platforms (Computer Experimental Teaching Center, Virtual Simulation Experimental Center for Network Engineering, and Tencent Cloud AI College), the Guangdong Laboratory of Artificial Intelligence and Digital Economy (Shenzhen), ten other provincial-level and ten municipal-level platforms.